What is Mechanobiology?
Mechanobiology is the study of how physical forces and mechanical properties of cells and tissues influence biological processes. It reveals that cells are not just biochemically reactive — they are also mechanically intelligent.
Our Approach
We use low-frequency ultrasound (LFU) to deliver gentle mechanical stimulation to tissues and cells. This reactivates healthy signaling pathways in aged or senescent cells — promoting repair, reducing inflammation, and restoring function.
How It Works
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Non-invasive ultrasound targets tissues at the cellular level.
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Mechanical signals re-engage cytoskeletal dynamics and nuclear tension.
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Senescent cells are rejuvenated, leading to improved tissue function.
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No drugs, no gene editing — just physics-based stimulation.
Scientific Foundations
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Mechanobiologics builds on peer-reviewed research by Dr. Michael Sheetz and collaborators.
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Our clinical trials of Osteoarthristis are ongoing
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Research highlights are viewable below and DOWNLOADABLE
Research Highlights
Intracellular membranes experience a cyclic stretch/relaxation in response to LFU
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Human Foreskin Fibroblasts were subjected to LFU and the mitochondrial membrane displacements were visualized using a modified super-resolution microscope.
Aged mouse without LFU treatment
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A 30 month old mouse received two months of sham treatment. It was placed in the bath without switching on the ultrasound. The treatment was twice weekly for 30 minutes each time.
Aged mouse after LFU treatment
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A 30 month old mouse received two months of LFU treatment. It was placed in the bath twice weekly for treatments of 30 minutes each.
