Milestones
Patents Pending:
Systems and Methods for Cancer Treatment: Publication number: 20220203138
Systems and Methods for Immersion Mechanotherapy: Publication number: 20220047894
Reversal of Cellular Senescence by Low Frequency Ultrasound: Publication number: 20240001155
Published breakthroughs:
Low Frequency Ultrasound Treatment Reduces Susceptibility to Salmonella Infection in Aged Mice.
Zangoui, P., Singh, E., Sheetz, M.P. and L.J. Kenney. Low Frequency Ultrasound Treatment Reduces Susceptibility to Salmonella Infection in Aged Mice. J. Bacteriol. 2025. 207(9), doi:10.1128/jb.00176-25. 2025.
Marchant ED, Singh E, Kureel S, Blair B, Kalenta H, Von Ruff ZD, Weldon KS, Lai Z, Sheetz MP, Rasmussen BB.Am J Physiol Endocrinol Metab. 2025 Jun 1;328(6):E899-E910. doi: 10.1152/ajpendo.00470.2024. Epub 2025 May 5.PMID: 40323206 Free PMC article.
Rejuvenation of Senescent Cells, In Vitro and In Vivo, by Low-Frequency Ultrasound.
Kureel SK, Maroto R, Aniqua M, Powell S, Singh E, Margadant F, Blair B, Rasmussen BB, Sheetz MP.Aging Cell. 2025 Jun;24(6):e70008. doi: 10.1111/acel.70008. Epub 2025 Mar 3.PMID: 40033886 Free PMC article.
Kureel, S. K.; Maroto, R.; Aniqua, M.; Powell, S.; Singh, E.; Margadant, F.; Blair, B.; Rasmussen, B. B.; Sheetz, M. P., Rejuvenation of Senescent Cells, In Vitro and In Vivo, by Low-Frequency Ultrasound. Aging Cell 2025, e70008.
Ultrasound-mediated mechanical forces activate selective tumor cell apoptosis.
Tijore A, Margadant F, Dwivedi N, Morgan L, Yao M, Hariharan A, Chew CAZ, Powell S, Bonney GK, Sheetz M.Bioeng Transl Med. 2024 Dec 30;10(2):e10737. doi: 10.1002/btm2.10737. eCollection 2025 Mar.PMID: 40060768 Free PMC article.
Cancer cells can be killed mechanically or with combinations of cytoskeletal inhibitors.
Tijore A, Yang B, Sheetz M.Front Pharmacol. 2022 Oct 10;13:955595. doi: 10.3389/fphar.2022.955595. eCollection 2022.PMID: 36299893 Free PMC article. Review.
Selective killing of transformed cells by mechanical stretch.
Tijore A, Yao M, Wang YH, Hariharan A, Nematbakhsh Y, Lee Doss B, Lim CT, Sheetz M.Biomaterials. 2021 Aug;275:120866. doi: 10.1016/j.biomaterials.2021.120866. Epub 2021 May 21.PMID: 34044258
Enhanced tumor cell killing by ultrasound after microtubule depolymerization.
Singh A, Tijore A, Margadant F, Simpson C, Chitkara D, Low BC, Sheetz M.Bioeng Transl Med. 2021 Jun 11;6(3):e10233. doi: 10.1002/btm2.10233. eCollection 2021 Sep.PMID: 34589605 Free PMC article.